Effect of choline and cholesterol on lipoprotein patterns of rats.

Serum lipid values (low-density lipoproteins, alpha lipoproteins and scrum cholesterol) are decreased in choline deficiency. It is believed that this is due specifically to a choline lack rather than to a nonspecific effect of a deficiency. The addition of cholesterol to :i choline deficient diet does not lead to hyperlipemia and hypercholesterolemia. It appears that dietary choline is one of the many requirements necessary for production of hyperlipemia and hypercholesterolemia. A metabolic interdependence between choline and cholesterol is pointed out in rats.